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Article

Human iPSC-based modeling of late-onset disease via progerin-induced aging.

Cell stem cell - 5 Dec 2013

Miller Justine D, Ganat Yosif M, Kishinevsky Sarah, Bowman Robert L, Liu Becky, Tu Edmund Y, Mandal Pankaj K, Vera Elsa, Shim Jae-won, Kriks Sonja, Taldone Tony, Fusaki Noemi, Tomishima Mark J, Krainc Dimitri, Milner Teresa A, Rossi Derrick J, Studer Lorenz

Abstract excerpt

Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset disorders. In this study, we describe a strategy for inducing aging-related features in human iPSC-derived lineages and apply it to the modeling of Parkinson's disease (PD). Our approach involves expression of progerin, a truncated...

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Identifiers

PMID: 24315443
DOI: 10.1016/j.stem.2013.11.006
PMCID: PMC4153390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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