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Tetrahedral DNA nanostructures, graphene and carbon nanodots-based electrochemiluminescent biosensor for BRCA1 gene mutation detection.

Talanta - 1 Mar 2025

García-Fernández Daniel, Gutiérrez-Gálvez Laura, López-Diego David, Luna Mónica, Torres Íñigo, Zamora Félix, Solera Jesús, García-Mendiola Tania, Lorenzo Encarnación

Abstract excerpt

In this study, we present a novel electrochemiluminescent DNA biosensor designed for detecting breast cancer type 1 (BRCA1) gene mutations. The biosensor integrates graphene nanosheets (Graph-NS), tetrahedral DNA nanostructures (TDNs), and carbon nanodots (CNDs) to enhance sensitivity and specificity. Graph-NS are employed to structure the transducer and serve as a platform for DNA immobilization. TDNs are...

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Identifiers

PMID: 39577381
DOI: 10.1016/j.talanta.2024.127182

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