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Simultaneous EGFR mutation detection using a sensitive dual-target biosensor based on 3D hollow carbon nanosphere synergy with circular bipedal DNA walkers.

Mikrochimica acta - 20 Aug 2025

He Linxin, Wei Yuxin, Chen Cizhi, Li Chuanhai, Xu Ying, Chen Mei

Abstract excerpt

A sensitive dual-target electrochemical biosensor was developed integrating circular bipedal DNA walkers with a three-dimensional hollow carbon nanospheres-tetrametallic nanoparticle (3D HCNs-TT NPs) modified platform, enabling concurrent detection of two critical epidermal growth factor receptor (EGFR) exon 19 mutations: E746_A750 deletion (Mut DNA A) and L747_S752delinsS (Mut DNA B). The circular bipedal DNA...

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PMID: 40833639
DOI: 10.1007/s00604-025-07453-x

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EGFR

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