Article
MICA variant promotes allosensitization after kidney transplantation.
Journal of the American Society of Nephrology : JASN - 1 May 2013
Tonnerre Pierre, Gérard Nathalie, Chatelais Mathias, Poli Caroline, Allard Stéphanie, Cury Sylvie, Bressollette Céline, Cesbron-Gautier Anne, Charreau Béatrice
Abstract excerpt
MHC class I-related chain A (MICA) antigens are surface glycoproteins strongly implicated in innate immunity, and the MICA gene is highly polymorphic. Clinical observations suggest a role for donor MICA antigens expressed on transplant endothelial cells in the alloimmune response, but the effect of MICA genotype is not well understood. Here, we investigated the immunologic effect of the A5.1 mutation, related to...
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