Article
Donor-recipient mismatches in MHC class I chain-related gene A in unrelated donor transplantation lead to increased incidence of acute graft-versus-host disease.
Blood - 1 Oct 2009
Parmar Simrit, Del Lima Marcos, Zou Yizhou, Patah Poliana A, Liu Ping, Cano Pedro, Rondon Gabriela, Pesoa Susana, de Padua Silva Leandro, Qazilbash Muzaffar H, Hosing Chitra, Popat Uday, Kebriaei Partow, Shpall Elizabeth J, Giralt Sergio, Champlin Richard E, Stastny Peter, Fernandez-Vina Marcelo
Abstract excerpt
The polymorphic products of major histocompatibility complex class I-related chain A (MICA) genes are important in solid organ transplantation rejection. MICA expression is limited to gut epithelium and may play a role in triggering acute graft-versus-host disease (aGVHD). A total of 236 recipients of unrelated donor transplantation were studied. Donor-recipient human leukocyte antigen (HLA) match was 10/10 human...
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