Article
Killer immunoglobulin-like receptor (KIR) and HLA genotypes affect the outcome of allogeneic kidney transplantation.
PloS one - 1 Jan 2012
Nowak Izabela, Magott-Procelewska Maria, Kowal Agnieszka, Miazga Maciej, Wagner Marta, Niepiekło-Miniewska Wanda, Kamińska Małgorzata, Wiśniewski Andrzej, Majorczyk Edyta, Klinger Marian, Łuszczek Wioleta, Pawlik Andrzej, Płoski Rafał, Barcz Ewa, Senitzer David, Kuśnierczyk Piotr
Abstract excerpt
BACKGROUND: Recipient NK cells may detect the lack of recipient's (i.e., self) HLA antigens on donor renal tissue by means of their killer cell immunoglobulin-like receptors (KIRs). KIR genes are differently distributed in individuals, possibly contributing to differences in response to allogeneic graft. METHODOLOGY/PRINCIPAL FINDINGS: We compared frequencies of 10 KIR genes by PCR-SSP in 93 kidney graft...
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