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Article

DUSP6 regulates Notch1 signalling in colorectal cancer

21 Nov 2024

Abstract excerpt

Notch1 plays various roles in cancer development, and Notch1-induced transactivation is controlled by phosphorylation of its cleaved intracellular domain. However, it is unclear whether there are phosphatases capable of dephosphorylating the cleaved Notch1 transmembrane/intracellular region (NTM) to regulate its function. Here, we show that DUSP6 can function as a phosphatase for Notch1, thereby regulating NTM...

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PMID: 39572549
DOI: 10.1038/s41467-024-54383-y

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