Article

DUSP6 regulates NOTCH1 signaling in colorectal cancer

2023-05-23

Abstract excerpt

<title>Abstract</title> <p>Notch1 plays various roles in cancer development and Notch1-induced transactivation is controlled by phosphorylation of its cleaved intracellular domain. However, if there are phosphatases that are able to dephosphorylate cleaved Notch1 intracellular domain (NICD) to regulate its function is unclear. Here we showed that DUSP6 is a Notch1 phosphatase which regulates NICD stability hence...

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Literature Corpus work: d5f11e25-4f14-5c8a-95f7-90bbcaab8d08
DOI: 10.21203/rs.3.rs-2931411/v1

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