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Article

Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype.

International journal of cancer - 1 Jan 2012

Wong Victor Chun Lam, Chen Han, Ko Josephine Mun Yee, Chan Kwok Wah, Chan Yuen Piu, Law Simon, Chua Daniel, Kwong Dora Lai-Wan, Lung Hong Lok, Srivastava Gopesh, Tang Johnny Cheuk On, Tsao Sai Wah, Zabarovsky Eugene R, Stanbridge Eric J, Lung Maria Li

Abstract excerpt

Suppressive effects of DUSP6 in tumorigenesis and EMT-associated properties were observed. Dual-specificity phosphatase (DUSP6) is a MAP kinase phosphatase (MKP) negatively regulating the activity of ERK, one of the major molecular switches in the MAPK signaling cascade propagating the signaling responses during malignancies. The impact of DUSP6 in EMT and its contribution to tumor dissemination has not yet been...

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Identifiers

PMID: 21387288
DOI: 10.1002/ijc.25970

Genes

DUSP6

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Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype.PMID 21387288Read ↗

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