Article
Genetic and phenotypic architecture of human myocardial trabeculation.
Nature cardiovascular research - 1 Dec 2024
McGurk Kathryn A, Qiao Mengyun, Zheng Sean L, Sau Arunashis, Henry Albert, Ribeiro Antonio Luiz P, Ribeiro Antônio H, Ng Fu Siong, Lumbers R Thomas, Bai Wenjia, Ware James S, O'Regan Declan P
Abstract excerpt
Cardiac trabeculae form a network of muscular strands that line the inner surfaces of the heart. Their development depends on multiscale morphogenetic processes and, while highly conserved across vertebrate evolution, their role in the pathophysiology of the mature heart is not fully understood. Here we report variant associations across the allele frequency spectrum for trabecular morphology in 47,803...
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