Article
Genetic and functional insights into the fractal structure of the heart.
Nature - 1 Aug 2020
Meyer Hannah V, Dawes Timothy J W, Serrani Marta, Bai Wenjia, Tokarczuk Paweł, Cai Jiashen, de Marvao Antonio, Henry Albert, Lumbers R Thomas, Gierten Jakob, Thumberger Thomas, Wittbrodt Joachim, Ware James S, Rueckert Daniel, Matthews Paul M, Prasad Sanjay K, Costantino Maria L, Cook Stuart A, Birney Ewan, O'Regan Declan P
Abstract excerpt
The inner surfaces of the human heart are covered by a complex network of muscular strands that is thought to be a remnant of embryonic development1,2. The function of these trabeculae in adults and their genetic architecture are unknown. Here we performed a genome-wide association study to investigate image-derived phenotypes of trabeculae using the fractal analysis of trabecular morphology in 18,096...
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