The PRIMED Consortium: Reducing disparities in polygenic risk assessment.

doi:10.1016/j.ajhg.2024.10.010

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The PRIMED Consortium: Reducing disparities in polygenic risk assessment.

American journal of human genetics - 5 Dec 2024

Kullo Iftikhar J, Conomos Matthew P, Nelson Sarah C, Adebamowo Sally N, Choudhury Ananyo, Conti David, Fullerton Stephanie M, Gogarten Stephanie M, Heavner Ben, Hornsby Whitney E, Kenny Eimear E, Khan Alyna, Khera Amit V, Li Yun, Martin Iman, Mercader Josep M, Ng Maggie, Raffield Laura M, Reiner Alex, Rowley Robb, Schaid Daniel, Stilp Adrienne, Wiley Ken, Wilson Riley, Witte John S, Natarajan Pradeep

Abstract excerpt

By improving disease risk prediction, polygenic risk scores (PRSs) could have a significant impact on health promotion and disease prevention. Due to the historical oversampling of populations with European ancestry for genome-wide association studies, PRSs perform less well in other, understudied populations, leading to concerns that clinical use in their current forms could widen health care disparities. The...

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PMID: 39561770
DOI: 10.1016/j.ajhg.2024.10.010
PMCID: PMC11639095

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