Article
The application of sphingomyelin in mediating the causal role of the T-cell surface glycoprotein CD5 in Crohn's disease: A two-step Mendelian randomization study.
Medicine - 15 Nov 2024
Li Xiao, Yao Xin, Wen Jieying, Chen Qiaoling, Zhu Ziming, Zhang Xinyue, Wang Song, Lan Weixuan, Huang Yunsi, Tang Shanneng, Zhou Xuan, Han Xuedong, Zhang Tao
Abstract excerpt
To examine the possible causative association between Crohn disease (CD) and the T-cell surface glycoprotein CD5 and to ascertain whether sphingomyelin (SM) functions as a mediator. We conducted a two-step Mendelian randomization (MR) study to further explore the pathogenesis of Crohn and its related targets. MR study was performed on CD5 and CD using summary-level data from a genome-wide association study....
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