Article
Explore key genes of Crohn's disease based on glycerophospholipid metabolism: A comprehensive analysis Utilizing Mendelian Randomization, Multi-Omics integration, Machine Learning, and SHAP methodology.
International immunopharmacology - 15 Nov 2024
Chen Changan, Quan Juanhua, Chen Xintian, Yang Tingmei, Yu Caiyuan, Ye Shicai, Yang Yuping, Wu Xiu, Jiang Danxian, Weng Yijie
Abstract excerpt
BACKGROUND AND AIMS: Crohn's disease (CD) is a chronic, complex inflammatory condition with increasing incidence and prevalence worldwide. However, the causes of CD remain incompletely understood. We identified CD-related metabolites, inflammatory factors, and key genes by Mendelian randomization (MR), multi-omics integration, machine learning (ML), and SHAP. METHODS: We first performed a mediation MR analysis on...
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