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Article

Uncovering Mediating Mechanisms Linking Immune Cells to Systemic Lupus Erythematosus: Insights into Mendelian Randomization.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Liu Zenghui, Kuang Lu, Zhao Jiaxing, Yin Huayu, Liu Xuehui, Liu Dabin, Wu Shaoguo, Wu Limei

Abstract excerpt

INTRODUCTION: Systemic lupus erythematosus (SLE) involves dysregulated immune cell function, though its exact pathogenic mechanisms remain unclear. METHODS: We performed a two-sample Mendelian randomization (MR) study using extensive GWAS summary statistics, covering 731 immune cell phenotypes, 91 inflammatory proteins, 179 lipid types, 1,400 blood metabolites, and SLE cases. The analysis aimed to evaluate causal...

Read the complete abstract on PubMed

Topics

Humans
Lupus Erythematosus, Systemic
Mendelian Randomization Analysis
Genome-Wide Association Study
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Inflammation Mediators

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 41935394
DOI: 10.2174/0118715303407042251210161902

Genes

CCR2
CD28
CD4

Provenance

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