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Article

Gut Microbiota Mediates the Relationship Between Immune Cells and Familial Hypercholesterolemia: A Mendelian Randomization Study.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Liang Shuwei, Zhou Zeyu, Wang Siming, Xue Qian, Wu Aoni, Yang Haopeng, Sun Qiyu

Abstract excerpt

INTRODUCTION: Although extensive studies have revealed the critical role of immune cells in the pathogenesis of Familial Hypercholesterolemia (FH), the interplay between immune cells and gut microbiota and their potential mediating effects in developing this disease still lacks systematic investigation. This study aimed to investigate the potential causal effects of immune cells on FH and evaluate the mediating...

Read the complete abstract on PubMed

Topics

Humans
Mendelian Randomization Analysis
Gastrointestinal Microbiome
Genome-Wide Association Study
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Hyperlipoproteinemia Type II

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 42765181
DOI: 10.2174/0118715303441505260410094518
PMCID: PMC13673436

Genes

FH
CD4
CD33

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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