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Article

CRISPR-Cas9-based approaches for genetic analysis and epistatic interaction studies in Coxiella burnetii.

mSphere - 19 Dec 2024

Steiner Samuel, Roy Craig R

Abstract excerpt

Coxiella burnetii is an obligate intracellular bacterial pathogen that replicates to high numbers in an acidified lysosome-derived vacuole. Intracellular replication requires the Dot/Icm type IVB secretion system, which translocates over 100 different effector proteins into the host cell. Screens employing random transposon mutagenesis have identified several C. burnetii effectors that play an important role in...

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Identifiers

PMID: 39560384
DOI: 10.1128/msphere.00523-24
PMCID: PMC11656778

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