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Article

Identification of OmpA, a Coxiella burnetii protein involved in host cell invasion, by multi-phenotypic high-content screening.

PLoS pathogens - 1 Mar 2014

Martinez Eric, Cantet Franck, Fava Laura, Norville Isobel, Bonazzi Matteo

Abstract excerpt

Coxiella burnetii is the agent of the emerging zoonosis Q fever. This pathogen invades phagocytic and non-phagocytic cells and uses a Dot/Icm secretion system to co-opt the endocytic pathway for the biogenesis of an acidic parasitophorous vacuole where Coxiella replicates in large numbers. The study of the cell biology of Coxiella infections has been severely hampered by the obligate intracellular nature of this...

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PMID: 24651569
DOI: 10.1371/journal.ppat.1004013
PMCID: PMC3961360

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