Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CCR5 mediates rheumatoid arthritis progression by promoting the activation and proliferation of non-classical Th1 cells.

International journal of rheumatic diseases - 1 Nov 2024

Miao Jinlin, Zhang Bei, Sun Haoyang, Zhang Peiyan, Shen Haomiao, Wang Jiawei, Jia Junfeng, Zhang Kui, Zheng Zhaohui, Zhu Ping

Abstract excerpt

AIM: Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by immune dysegulation, including an immune imbalance due to abnormal activation of non-classical Th1 cells (CD161+ Th1). This study investigated the effects of CCR5 on the activation and proliferation of CD161+ Th1 and their pathogenicity in patients with RA. METHODS: The study was conducted on 53 patients with RA and 32 age- and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokines

Share to Disease Progression

Share to Lymphocyte Activation

Share to Receptors, CCR5

Share to Synovial Fluid

Share to Th1 Cells

Source

Identifiers

PMID: 39558608
DOI: 10.1111/1756-185X.15370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CCR5 mediates rheumatoid arthritis progression by promoting the activation and proliferation of non-classical Th1 cells.PMID 39558608Read ↗

Increased plasticity of non-classic Th1 cells toward the Th17 phenotypeSemantic proximity Read ↗

Functional phenotype of synovial monocytes modulating inflammatory T-cell responses in rheumatoid arthritis (RA).Semantic proximity Read ↗

Molecular mechanisms underpinning T helper 17 cell heterogeneity and functions in rheumatoid arthritis.Semantic proximity Read ↗

PLZF regulates CCR6 and is critical for the acquisition and maintenance of the Th17 phenotype in human cells.Semantic proximity Read ↗

Natural killer-like B cells promote Th17 cell differentiation and exacerbate rheumatoid arthritisSemantic proximity Read ↗

High miR-451 expression in peripheral blood mononuclear cells from subjects at risk of developing rheumatoid arthritisSemantic proximity Read ↗

KLRB1 defines an activated phenotype of CD4+ T cells and shows significant upregulation in patients with primary Sjögren's syndrome.Semantic proximity Read ↗

CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages.Semantic proximity Read ↗

Activated Platelets Convert CD14+CD16- Into CD14+CD16+ Monocytes With Enhanced FcγR-Mediated Phagocytosis and Skewed M2 Polarization.Semantic proximity Read ↗

Arthritis in systemic lupus erythematosus is characterized by local IL-17A and IL-6 expressionSemantic proximity Read ↗

CD5L insufficiency exacerbates skeletal joint damage in rheumatoid arthritisSemantic proximity Read ↗

Human CCR6+ Th Cells Show Both an Extended Stable Gradient of Th17 Activity and Imprinted Plasticity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.