Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KLRB1 defines an activated phenotype of CD4+ T cells and shows significant upregulation in patients with primary Sjögren's syndrome.

International immunopharmacology - 30 May 2024

Zhang Zhonghui, Bahabayi Ayibaota, Liu Danni, Hasimu Ainizati, Zhang Yangyang, Guo Siyu, Liu Ruiqing, Zhang Ke, Li Qi, Xiong Ziqi, Wang Pingzhang, Liu Chen

Abstract excerpt

OBJECTIVE: This study aimed to investigate the role of KLRB1 (CD161) in human CD4+ T cells and elucidate its significance in primary Sjögren's syndrome (pSS). METHODS: Peripheral blood samples from 37 healthy controls and 44 pSS patients were collected. The publicly available single-cell RNA-Seq data from pSS patient PBMCs were utilized to analyse KLRB1 expression in T cells. KLRB1-expressing T lymphocyte subset...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokines

Share to Ki-67 Antigen

Share to Lymphocyte Activation

Share to Phenotype

Share to Sjogren's Syndrome

Share to Up-Regulation

Source

Identifiers

PMID: 38636371
DOI: 10.1016/j.intimp.2024.112072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KLRB1 defines an activated phenotype of CD4+ T cells and shows significant upregulation in patients with primary Sjögren's syndrome.PMID 38636371Read ↗

Analysis of Gene Expression and TCR/B Cell Receptor Profiling of Immune Cells in Primary Sjögren’s Syndrome by Single-Cell SequencingSemantic proximity Read ↗

Single-Cell RNA Sequencing Reveals the Expansion of Cytotoxic CD4+ T Lymphocytes and a Landscape of Immune Cells in Primary Sjögren’s SyndromeSemantic proximity Read ↗

Expression and regulatory characteristics of peripheral blood immune cells in primary Sjögren’s syndrome patients using single-cell transcriptomicSemantic proximity Read ↗

Integrated Bioinformatics and Validation Reveal Potential Biomarkers Associated With Progression of Primary Sjögren’s SyndromeSemantic proximity Read ↗

Transcriptome Sequencing Reveals Potential Roles of ICOS in Primary Sjögren’s SyndromeSemantic proximity Read ↗

Single-cell profiling reveals pathogenic role and differentiation trajectory of granzyme K+CD8+ T cells in primary Sjögren’s syndromeSemantic proximity Read ↗

Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells.Semantic proximity Read ↗

Identification and verification of inflammatory biomarkers for primary sjögren’s syndromeSemantic proximity Read ↗

Differential long non-coding RNA expression profile and function analysis in primary Sjogren’s syndromeSemantic proximity Read ↗

Identification and Validation of IFI44 as a Novel Biomarker for Primary Sjögren’s SyndromeSemantic proximity Read ↗

LncRNA and mRNA expression profile of peripheral blood mononuclear cells in primary Sjögren’s syndrome patientsSemantic proximity Read ↗

Sjögren's syndrome: one year in review 2022Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.