Article
Dysfunction of endothelial and smooth muscle cells in small arteries of a mouse model of Marfan syndrome.
British journal of pharmacology - 1 Nov 2009
Syyong H T, Chung A W Y, Yang H H C, van Breemen C
Abstract excerpt
BACKGROUND AND PURPOSE: Marfan syndrome, a connective tissue disorder caused by mutations in FBN1 encoding fibrillin-1, results in life-threatening complications in the aorta, but little is known about its effects in resistance vasculature. EXPERIMENTAL APPROACH: Second-order mesenteric arteries from mice at 3, 6 and 10 months of age (n= 30) heterozygous for the Fbn1 allele encoding a cysteine substitution...
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