Article

Reduced platelet forces underlie impaired hemostasis in mouse models of <i>MYH9</i> -related disease

2021-11-10

Abstract excerpt

MYH9-related disease patients with mutations in the contractile protein non-muscle myosin heavy chain IIA display, among others, macrothrombocytopenia and a mild to moderate bleeding tendency. In this study, we used three mouse lines, each with one point mutation in the Myh9 gene at positions 702, 1424, or 1841, to investigate mechanisms underlying the increased bleeding risk. Agonist-induced activation of Myh9...

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Literature Corpus work: b254c122-cc85-5630-a2d7-db8f1c7b4d9a
DOI: 10.1101/2021.11.10.468045

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