The influence of FAAH genetic variation on physiological, cognitive, and neural signatures of fear acquisition and extinction learning in women with PTSD.

doi:10.1016/j.nicl.2021.102922

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Article

The influence of FAAH genetic variation on physiological, cognitive, and neural signatures of fear acquisition and extinction learning in women with PTSD.

NeuroImage. Clinical - 1 Jan 2022

Crombie Kevin M, Privratsky Anthony A, Schomaker Chloe M, Heilicher Mickela, Ross Marisa C, Sartin-Tarm Anneliis, Sellnow Kyrie, Binder Elisabeth B, Andrew James G, Cisler Josh M

Abstract excerpt

BACKGROUND: Posttraumatic Stress Disorder (PTSD) is commonly treated with exposure-based cognitive therapies that are based on the principles of fear acquisition and extinction learning. Elevations in one of the major endocannabinoids (anandamide) either via inhibition of the primary degrading enzyme (fatty acid amide hydrolase; FAAH) or via a genetic variation in the FAAH gene (C385A; rs324420) has resulted in...

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Identifiers

PMID: 34952353
DOI: 10.1016/j.nicl.2021.102922
PMCID: PMC8715233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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