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[Clinical application of targeted next generation sequencing in detecting rifampicin and rifabutin resistance in tuberculosis patients].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] - 6 Nov 2024

Wu C, Yang S J, Lai W J, Qu J X

Abstract excerpt

To evaluate the clinical value of targeted next generation sequencing (tNGS) in diagnosing rifampicin and rifabutin resistance in tuberculosis patients. In this retrospective cohort study, 119 culture-positive Mycobacterium tuberculosis (MTB) strains from tuberculosis patients in Shenzhen Third People's Hospital from 2020 to 2023 were collected, then tNGS was performed to detect mutations of rpoB gene. Fourteen...

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Identifiers

PMID: 39537404
DOI: 10.3760/cma.j.cn112150-20240319-00226

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