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Evaluating the efficacy of whole genome sequencing in predicting susceptibility profiles for first-line antituberculosis drugs.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Jan 2025

Ghodousi Arash, Omrani Maryam, Torri Stefania, Teymouri Hedyeh, Russo Giulia, Vismara Chiara, Matteelli Alberto, Codecasa Luigi Ruffo, Cirillo Daniela Maria

Abstract excerpt

OBJECTIVES: This study aimed to examine the efficacy of whole genome sequencing (WGS) in accurately predicting susceptibility profiles, potentially eliminating the need for conventional phenotypic drug susceptibility testing (pDST) for first-line antituberculosis drugs in routine tuberculosis diagnosis. METHODS: Over the period of 2017 to 2020, 1114 Mycobacterium tuberculosis complex isolates were collected with...

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PMID: 39341416
DOI: 10.1016/j.cmi.2024.09.024

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