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Sensitive diagnosis of paucibacillary tuberculosis with targeted next-generation sequencing: a molecular diagnostic study

26 Mar 2025

Abstract excerpt

BACKGROUND: Targeted next-generation sequencing (tNGS) enables high-performance tuberculosis (TB) diagnosis and drug resistance prediction directly from clinical samples. However, its applicability to paucibacillary TB, including pediatric TB and extrapulmonary TB (EPTB), has been less explored. We aimed to evaluate the performance of tNGS in these challenging TB presentations. METHODS: We prospectively and...

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PMID: 40140883
DOI: 10.1186/s12916-025-03996-1

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