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Article

Comparison of targeted next-generation sequencing and the Xpert MTB/RIF assay for detection of Mycobacterium tuberculosis in clinical isolates and sputum specimens.

Microbiology spectrum - 2 May 2024

Zhang Hongtai, Dai Xiaowei, Hu Peilei, Tian Lili, Li Chuanyou, Ding Beichuan, Yang Xinyu, He Xiaoxin

Abstract excerpt

Targeted next-generation sequencing (tNGS) can be used to perform Mycobacterium tuberculosis (MTB) complex-specific amplification or target capture directly from sputum samples, yielding simultaneous coverage of many genes and DNA regions associated with antimicrobial resistance (AMR). Performance comparisons of tNGS and another molecular testing tool, Xpert MTB/rifampicin (RIF), have been empirical. Here, using...

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Identifiers

PMID: 38602399
DOI: 10.1128/spectrum.04098-23
PMCID: PMC11064545

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