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Article

Distinct evolutionary trajectories following loss of RNA interference in Cryptococcus neoformans.

Proceedings of the National Academy of Sciences of the United States of America - 19 Nov 2024

Huang Jun, Larmore Connor J, Priest Shelby J, Xu Ziyan, Dietrich Fred S, Yadav Vikas, Magwene Paul M, Sun Sheng, Heitman Joseph

Abstract excerpt

While increased mutation rates typically have negative consequences in multicellular organisms, hypermutation can be advantageous for microbes adapting to the environment. Previously, we identified two hypermutator Cryptococcus neoformans clinical isolates that rapidly develop drug resistance due to transposition of a retrotransposon, Cnl1. Cnl1-mediated hypermutation is caused by a nonsense mutation in a gene...

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Share to Cryptococcus neoformans
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 39536081
DOI: 10.1073/pnas.2416656121
PMCID: PMC11588098

Genes

ZNF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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