Article

Distinct evolutionary trajectories following loss of RNA interference in <i>Cryptococcus neoformans</i>

2024-08-16

Abstract excerpt

While increased mutation rates typically have negative consequences in multicellular organisms, hypermutation can be advantageous for microbes adapting to the environment. Previously, we identified two hypermutator Cryptococcus neoformans clinical isolates that rapidly develop drug resistance due to transposition of a retrotransposon, Cnl1. Cnl1-mediated hypermutation is caused by a nonsense mutation in the gene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 96241c9b-67a1-52f3-845e-c19aa88a1c8a
DOI: 10.1101/2024.08.15.608186

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct evolutionary trajectories following loss of RNA interference in <i>Cryptococcus neoformans</i>DOI 10.1101/2024.08.15.608186Read

Distinct evolutionary trajectories following loss of RNA interference in Cryptococcus neoformans.Semantic proximity Read

Rampant transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of a human fungal pathogenSemantic proximity Read

Rampant transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of a human fungal pathogenSemantic proximity Read

Uncontrolled transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of Cryptococcus neoformansSemantic proximity Read

Saturation transposon mutagenesis enables genome-wide identification of genes required for growth and fluconazole resistance in the human fungal pathogen <i>Cryptococcus neoformans</i>Semantic proximity Read

A spontaneous mutation in DNA polymerase POL3 during in vitro passaging causes a hypermutator phenotype in Cryptococcus species.Semantic proximity Read

Transposon mobilization in the human fungal pathogen <i>Cryptococcus deneoformans</i> is mutagenic during infection and promotes drug resistance <i>in vitro</i>Semantic proximity Read

Genome restructuring and lineage diversification of<i>Cryptococcus neoformans</i>during chronic infection of human hostsSemantic proximity Read

Genome-wide analysis of heat stress-stimulated transposon mobility in the human fungal pathogen <i>Cryptococcus deneoformans</i>Semantic proximity Read

Identification of essential genes and fluconazole resistance genes in <i>Candida glabrata</i> by profiling of <i>Hermes</i> transposon insertionsSemantic proximity Read

Gene Network Polymorphism Illuminates Loss and Retention of Novel RNAi Silencing Components in the Cryptococcus Pathogenic Species ComplexSemantic proximity Read

RNAi epimutations conferring antifungal drug resistance are inheritableSemantic proximity Read