Article
The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.
Science (New York, N.Y.) - 25 Feb 2005
Loftus Brendan J, Fung Eula, Roncaglia Paola, Rowley Don, Amedeo Paolo, Bruno Dan, Vamathevan Jessica, Miranda Molly, Anderson Iain J, Fraser James A, Allen Jonathan E, Bosdet Ian E, Brent Michael R, Chiu Readman, Doering Tamara L, Donlin Maureen J, D'Souza Cletus A, Fox Deborah S, Grinberg Viktoriya, Fu Jianmin, Fukushima Marilyn, Haas Brian J, Huang James C, Janbon Guilhem, Jones Steven J M, Koo Hean L, Krzywinski Martin I, Kwon-Chung June K, Lengeler Klaus B, Maiti Rama, Marra Marco A, Marra Robert E, Mathewson Carrie A, Mitchell Thomas G, Pertea Mihaela, Riggs Florenta R, Salzberg Steven L, Schein Jacqueline E, Shvartsbeyn Alla, Shin Heesun, Shumway Martin, Specht Charles A, Suh Bernard B, Tenney Aaron, Utterback Terry R, Wickes Brian L, Wortman Jennifer R, Wye Natasja H, Kronstad James W, Lodge Jennifer K, Heitman Joseph, Davis Ronald W, Fraser Claire M, Hyman Richard W
Abstract excerpt
Cryptococcus neoformans is a basidiomycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its approximately 20-megabase genome, which contains approximately 6500 intron-rich gene structures and encodes a transcriptome abundant in alternatively spliced and antisense messages. The genome is rich in transposons, many...
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