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Article

A spontaneous mutation in DNA polymerase POL3 during in vitro passaging causes a hypermutator phenotype in Cryptococcus species.

DNA repair - 1 Feb 2020

Boyce Kylie J, Cao Chengjun, Xue Chaoyang, Idnurm Alexander

Abstract excerpt

Passaging of microbes in vitro can lead to the selection of microevolved derivatives with differing properties to their original parent strains. One well characterised instance is the phenotypic differences observed between the series of strains derived from the type strain of the human pathogenic fungus Cryptococcus neoformans. A second case was reported in the close relative Cryptococcus deneoformans, in which...

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Identifiers

PMID: 31838381
DOI: 10.1016/j.dnarep.2019.102751
PMCID: PMC7542539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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