Landscape of essential growth and fluconazole-resistance genes in the human fungal pathogen Cryptococcus neoformans

Abstract excerpt

Fungi can cause devastating invasive infections, typically in immunocompromised patients. Treatment is complicated both by the evolutionary similarity between humans and fungi and by the frequent emergence of drug resistance. Studies in fungal pathogens have long been slowed by a lack of high-throughput tools and community resources that are common in model organisms. Here we demonstrate a high-throughput...

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