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Article

Bidirectional Risk Modulator and Modifier Variant of Dilated and Hypertrophic Cardiomyopathy in BAG3.

JAMA cardiology - 1 Dec 2024

Park Joseph, Levin Michael G, Zhang David, Reza Nosheen, Mead Jonathan O, Carruth Eric D, Kelly Melissa A, Winters Alex, Kripke Colleen M, Judy Renae L, Damrauer Scott M, Owens Anjali T, Bastarache Lisa, Verma Anurag, Kinnamon Daniel D, Hershberger Ray E, Ritchie Marylyn D, Rader Daniel J

Abstract excerpt

Importance: The genetic factors that modulate the reduced penetrance and variable expressivity of heritable dilated cardiomyopathy (DCM) are largely unknown. BAG3 genetic variants have been implicated in both DCM and hypertrophic cardiomyopathy (HCM), nominating BAG3 as a gene that harbors potential modifier variants in DCM. Objective: To interrogate the clinical traits and diseases associated with BAG3 coding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39535783
DOI: 10.1001/jamacardio.2024.3547
PMCID: PMC11561727

Genes

BAG3
TTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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