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Article

Rare and Common Genetic Variation Underlying the Risk of Hypertrophic Cardiomyopathy in a National Biobank.

JAMA cardiology - 1 Jul 2022

Biddinger Kiran J, Jurgens Sean J, Maamari Dimitri, Gaziano Liam, Choi Seung Hoan, Morrill Valerie N, Halford Jennifer L, Khera Amit V, Lubitz Steven A, Ellinor Patrick T, Aragam Krishna G

Abstract excerpt

Importance: Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death in young people. Although rare genetic variants are well-established contributors to HCM risk, common genetic variants have recently been implicated in disease pathogenesis. Objective: To assess the contributions of rare and common genetic variation to risk of HCM in the general population. Design, Setting, and Participants:...

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Identifiers

PMID: 35583889
DOI: 10.1001/jamacardio.2022.1061
PMCID: PMC9118016

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