Article

Polygenic Background and Penetrance of Pathogenic Variants in Hypertrophic and Dilated Cardiomyopathies

2025-06-22

Abstract excerpt

<h4>Importance</h4> Polygenic background modifies variant penetrance in hypertrophic (HCM) and dilated (DCM) cardiomyopathy, diseases with opposing morphologic characteristics and inversely related genetic pathways. Whether polygenic susceptibility for one disease protects against monogenic risk for the other remains unexplored. <h4> <h4>Objective: </h4> </h4> To characterize if polygenic background bidirectionall...

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Literature Corpus work: e03842e1-f8fb-5fb9-a233-7acbb5501426
DOI: 10.1101/2025.06.20.25329138

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