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Novel virulence determinants in VP1 regulate the assembly of enterovirus-A71

13 Nov 2024

Abstract excerpt

Enterovirus-A71 (EV-A71) is the second most common causative agent after coxsackievirus A16 of hand, foot, and mouth disease. The capsids of EV-A71 consist of 60 copies of each of the four viral structural proteins (VP1-VP4). VP1 is highly exposed and surface accessible, playing a central role in virus particle assembly, attachment, and entry. To gain insight into the role of highly conserved residues at...

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PMID: 39535185
DOI: 10.1128/jvi.01655-24

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