Article
Mutation of the highly conserved amino acids in the N-terminal region of the EV-A71 VP1 protein impairs viral RNA release during virus entry.
Microbiology spectrum - 3 Mar 2026
Zhang Wenjing, Liu Yaru, Li Quanjie, Yi Dongrong, Liu Qian, Guo Saisai, Wang Jing, Zhao Jianyuan, Ma Ling, Ding Jiwei, Zhou Rui, Ren Yongcheng, Talpbek Yesem, Li Xiaoyu, Zhang Yongxin, Cen Shan
Abstract excerpt
Enterovirus A71 (EV-A71) causes hand-foot-mouth disease, which may progress to severe neurological and systemic complications in young children and infants. To deliver viral genomic RNA into the target cell for replication, the mature EV-A71 capsid particle undergoes drastic structural changes to become an expanded A particle, which is marked by the movement of the N-terminal region of viral protein VP1 from the...
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