Article
Complete genome sequencing and analysis of six enterovirus 71 strains with different clinical phenotypes.
Virology journal - 11 Apr 2013
Wen Hong-ling, Si Lu-ying, Yuan Xiao-jing, Hao Shu-bin, Gao Feng, Chu Fu-lu, Sun Cheng-xi, Wang Zhi-yu
Abstract excerpt
BACKGROUND: Hand, foot and mouth diseases (HFMD) caused by enterovirus 71(EV71) presents a broad spectrum of clinical manifestations ranging from mild febrile disease to fatal neurolocal disease. However, the mechanism of virulence is unknown. METHODS: We isolated 6 strains of EV71 from HFMD patients with or without neurological symptoms, and sequenced the whole genomes of the viruses to reveal the virulence...
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