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Mutations in VP1 and 5'-UTR affect enterovirus 71 virulence.

Scientific reports - 27 Apr 2018

Chang Ching-Kun, Wu Shang-Rung, Chen Ying-Chin, Lee Kuen-Jin, Chung Nai-Hsiang, Lu Yi-Ju, Yu Shu-Ling, Liu Chia-Chyi, Chow Yen-Hung

Abstract excerpt

Enterovirus 71 (EV71) is a major cause of hand, foot and mouth disease (HFMD). The current EV71 propagating in Vero (EV-V) or sub-passaged in RD (EV-R) cells was used as a pathogen. Interestingly, EV-R exhibited differential virulence; challenging human scavenger receptor class B2-expressing (hSCARB2-Tg) mice with EV71 revealed that EV-V was more virulent than EV-R: 100% of mice that received lethal amounts of...

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PMID: 29703921
DOI: 10.1038/s41598-018-25091-7
PMCID: PMC5923339

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