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Article

Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer.

Cancer research - 1 Feb 2025

Haanen Terrance J, Boock Sophie, Callahan Catherine G, Peris Irene, Zawacki Kaitlin P, Raines Brynne, Nino Charles A, Tran Brian, Harold Alexis, Hodges Onishi Gabrielle, Hinderman Matthew, Dowdican Amanda, Huang Wei, Taylor Derek J, Taylor Sarah E, Jackson Mark W, DiFeo Analisa, O'Connor Caitlin M, Narla Goutham

Abstract excerpt

Uterine serous carcinoma (USC) and uterine carcinosarcoma (UCS) tumors are uniquely aggressive, suggesting that the primary tumor is intrinsically equipped to disseminate and metastasize. Previous work identified mutational hotspots within PPP2R1A, which encodes the Aα scaffolding subunit of protein phosphatase 2A (PP2A), a heterotrimeric serine/threonine phosphatase. Two recurrent heterozygous PPP2R1A mutations,...

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Share to Carcinosarcoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystadenocarcinoma, Serous

Share to Epithelial-Mesenchymal Transition

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Share to Protein Phosphatase 2

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Source

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Identifiers

PMID: 39531506
DOI: 10.1158/0008-5472.CAN-24-1263
PMCID: PMC11788061

Genes

IGFBP2
PPP2R1A
IGF1R

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer.PMID 39531506Read ↗

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