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Article

The FOXA2 transcription factor is frequently somatically mutated in uterine carcinosarcomas and carcinomas.

Cancer - 1 Jan 2018

Le Gallo Matthieu, Rudd Meghan L, Urick Mary Ellen, Hansen Nancy F, Merino Maria J, Mutch David G, Goodfellow Paul J, Mullikin James C, Bell Daphne W

Abstract excerpt

BACKGROUND: Uterine carcinosarcomas (UCSs) are a rare but clinically aggressive form of cancer. They are biphasic tumors consisting of both epithelial and sarcomatous components. The majority of uterine carcinosarcomas are clonal, with the carcinomatous cells undergoing metaplasia to give rise to the sarcomatous component. The objective of the current study was to identify novel somatically mutated genes in UCSs....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28940304
DOI: 10.1002/cncr.30971
PMCID: PMC5735010

Genes

FOXA2
CHD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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