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Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein production

10 Nov 2024

Abstract excerpt

Abstract Helicobacter pylori is the primary cause of gastric cancer, and there is a need to discover new molecular targets for therapeutic intervention in H. pylori disease progression. We have previously shown that spermine oxidase (SMOX), the enzyme that catabolizes the back-conversion of the polyamine spermine to spermidine, is upregulated during infection and is associated with increased cancer risk in...

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PMID: 39523394
DOI: 10.1038/s41388-024-03218-7

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