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Article

Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H. pylori infection in mouse.

Helicobacter - 1 Oct 2006

Touati Eliette, Michel Valérie, Thiberge Jean-Michel, Avé Patrick, Huerre Michel, Bourgade Franck, Klungland Arne, Labigne Agnès

Abstract excerpt

BACKGROUND: Helicobacter pylori infection is associated with gastric cancer. Study with the Big Blue mouse model has reported a mutagenic effect associated with the H. pylori infection, as a result in part of oxidative DNA damage. The present work investigates the consequences of a deficiency in the OGG1 DNA glycosylase, responsible for the excision of 8-oxo guanine, on the inflammatory and genotoxic host...

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Source

Identifiers

PMID: 16961812
DOI: 10.1111/j.1523-5378.2006.00442.x

Genes

OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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