Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk

1 Jan 2012

Abstract excerpt

We have recently reported that Helicobacter pylori strains expressing the virulence factor cytotoxin-associated gene A (CagA) stimulate increased levels of spermine oxidase (SMO) in gastric epithelial cells, while cagA⁻ strains did not. SMO catabolizes the polyamine spermine and produces H₂O₂ that results in both apoptosis and DNA damage. Exogenous overexpression of CagA confirmed these findings, and knockdown or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Helicobacter pylori-related gastroenterology studies
Share to Parasitic Infections and Diagnostics
Share to Polyamine Metabolism and Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22555547
DOI: 10.4161/gmic.19345

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer riskPMID 22555547Read ↗

Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein productionSemantic proximity Read ↗

At the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer.Semantic proximity Read ↗

A Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact DiseaseSemantic proximity Read ↗

Statins’ Regulation of the Virulence Factors of Helicobacter pylori and the Production of ROS May Inhibit the Development of Gastric CancerSemantic proximity Read ↗

α-Difluoromethylornithine reduces gastric carcinogenesis by causing mutations in Helicobacter pylori cagYSemantic proximity Read ↗

Helicobacter pylori -Induced DNA Damage Is a Potential Driver for Human Gastric Cancer AGS CellsSemantic proximity Read ↗

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing CellsSemantic proximity Read ↗

Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cellsSemantic proximity Read ↗

Role of Helicobacter pylori CagA + Infection in Determining Oxidative DNA Damage in Gastric MucosaSemantic proximity Read ↗

Helicobacter pylori CagA status, mucosal oxidative damage and gastritis phenotype: a potential pathway to cancer?Semantic proximity Read ↗

Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent mannerSemantic proximity Read ↗

Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.