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Accumulation of abasic sites induces genomic instability in normal human gastric epithelial cells during Helicobacter pylori infection

24 Nov 2014

Abstract excerpt

Helicobacter pylori infection of the human stomach is associated with inflammation that leads to the release of reactive oxygen and nitrogen species (RONs), eliciting DNA damage in host cells. Unrepaired DNA damage leads to genomic instability that is associated with cancer. Base excision repair (BER) is critical to maintain genomic stability during RONs-induced DNA damage, but little is known about its role in...

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PMID: 25417725
DOI: 10.1038/oncsis.2014.42

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