Article
DNA damage in inflammation-related carcinogenesis and cancer stem cells.
Oxidative medicine and cellular longevity - 1 Jan 2013
Ohnishi Shiho, Ma Ning, Thanan Raynoo, Pinlaor Somchai, Hammam Olfat, Murata Mariko, Kawanishi Shosuke
Abstract excerpt
Infection and chronic inflammation have been recognized as important factors for carcinogenesis. Under inflammatory conditions, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from inflammatory and epithelial cells and result in oxidative and nitrative DNA damage, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-nitroguanine. The DNA damage can cause mutations and has...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
