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Article

Ca2+ signaling of pancreatic acinar cells in malignant hyperthermia susceptibility.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Dec 2024

Geyer Nikolett, Diszházi Gyula, Magyar Zsuzsanna É, Dienes Beatrix, Csáki Réka, Enyedi Péter, Madácsy Tamara, Maléth József, Almássy János

Abstract excerpt

BACKGROUND: Malignant hyperthermia susceptibility (MHS) and acute pancreatitis (AP) share a common cellular pathomechanism that is Ca2+-overload of the muscle fiber and the pancreatic acinar cell (PAC). In the muscle, gain-of-function mutations of the ryanodine receptor (RyR1) make the Ca2+-release mechanism hypersensitive to certain ligands, including Ca2+, volatile anaesthetics and succinylcholine, creating a...

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PMID: 39523163
DOI: 10.1016/j.pan.2024.11.005

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