Article
Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca2+ signalling.
Clinical and translational medicine - 1 Apr 2023
Sun Yuyang, Nascimento Da Conceicao Viviane, Chauhan Arun, Sukumaran Pramod, Chauhan Pooja, Ambrus Julian L, Vissink Arjan, Kroese Frans G M, Muniswamy Madesh, Mishra Bibhuti B, Singh Brij B
Abstract excerpt
BACKGROUND: Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease that is embodied by the loss of salivary gland function and immune cell infiltration, but the mechanism(s) are still unknown. The aim of this study was to understand the mechanisms and identify key factors that leads to the development and progression of pSS. METHODS: Immunohistochemistry staining, FACS analysis and cytokine levels were...
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