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Article

TP53 mutants in the tower of babel of cancer progression.

Human mutation - 1 Jun 2014

Bisio Alessandra, Ciribilli Yari, Fronza Gilberto, Inga Alberto, Monti Paola

Abstract excerpt

Loss-of-function, partial-function, altered-function, dominant-negative, temperature sensitive, interfering, contact, structural, unfolded, misfolded, dimeric, monomeric, non-cooperative, unstable, supertrans, superstable, intragenic suppressor. TP53 mutants are many, more than 2,000 in fact, and they can be very diverse. Sporadic; germline; gain-of-function (GoF); oncogenic; rebel-angel; yin and yang;...

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Identifiers

PMID: 24449472
DOI: 10.1002/humu.22514

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