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Article

Mouse Homolog of the Human TP53 R337H Mutation Reveals Its Role in Tumorigenesis.

Cancer research - 15 Sept 2018

Park Ji-Hoon, Li Jie, Starost Matthew F, Liu Chengyu, Zhuang Jie, Chen Jichun, Achatz Maria I, Kang Ju-Gyeong, Wang Ping-Yuan, Savage Sharon A, Hwang Paul M

Abstract excerpt

Inheritance of germline mutations in the tumor suppressor gene TP53 causes Li-Fraumeni syndrome (LFS), a cancer predisposition disorder. The arginine to histidine substitution at amino acid position 337 of p53 (R337H) is a founder mutation highly prevalent in southern and southeastern Brazil and is considered an LFS mutation. Although this mutation is of significant clinical interest, its role in tumorigenesis...

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Identifiers

PMID: 30042151
DOI: 10.1158/0008-5472.CAN-18-0016
PMCID: PMC6139041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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